Project Description

Cover for the film, Resistance. Features a light yellow background with yellow and blue dot arranged in an "x" shape.


2015 · Unrated · 1h 11m


Antibiotics were first massed-produced in the 1940s. Their ability to fight and kill bacteria revolutionized medicine and had profound effects on everything from agriculture to war. After less than 80 years, however, these miracle drugs are failing.

Resistant infections kill hundreds of thousands of people around the world each year, and there are now dozens of so-called Superbugs each with its own challenges and costs. How did this happen? Using microscopic footage, harrowing personal stories, and expert insights, this documentary clarifies the problem of antibiotic resistance, how we got to this point, and what we can do to turn the tide.

About the Filmmakers

Resistance was produced by Cinetic and directed by Michael Graziano. Find out more about the film at


“I hope Resistance will find a broad audience. After all, antibiotic resistance potentially affects everyone—the terrifying thing about antibiotic-resistant bacteria is that they can strike anyone under unexpected circumstances. Happily, almost anybody can take action, by boycotting meat and dairy producers that use antibiotics on healthy animals, and by declining to take antibiotics for infections that are probably viral as opposed to bacterial—like that cold I mentioned above. In fact, after watching Resistance, you won’t even think of asking your doctor for antibiotics unless you’re really sick—which is exactly how they’re meant to be used.” – L.V. Anderson. “This Terrifying Documentary Will Convince You to Start Caring About Antibiotic Abuse.” Slate. 20 Feb 2015

Resistance is surprisingly engaging, without descending into fear mongering. The film takes pains to convey the severity and urgency of the problem, but its treatment is level-headed. Graziano clearly recognizes the subtleties that have made antibiotic resistance a thorny issue, and the film’s scientific explanations are laudably cogent and clear.” – Zachary Miller. “Documentary Review: Resistance.” Yale Scientific. 23 Mar 2016

“This is an amazing movie. I’m beginning my foray into alternative health, and while I’ve known that ‘antibiotic over-use is bad’, I’ve not seen a more compelling, heartfelt, succinct, and thoughtful, article/book/movie (though I haven’t read missing microbes). its reach is far; environment, agriculture, medicine. In that sense, I feel like it leaves an open door into other areas of research you might find interesting. b/c at the end of the day, it all seems to boil down to the same thing: too little effective regulation of a greedy corporate industry that allows ppl to live the American dream but suffer the consequences of it all the same. buy local, live compactly, and love globally!” – A. Patel, Amazon

Resistance is an eye-opening documentary about antibiotic-resistant infections (“superbugs”) resulting from the indiscriminate use of antibiotics. The filmmaker succinctly explains how antibiotics were first developed and how microorganisms evolved due to the unchecked, and ill-informed, use of these life-saving drugs. The emotionally-charged stories of those impacted by antibiotic-resistant infections will persuade even the most stoic viewer that the medical establishment, the food industry, and citizens/consumers must take steps to reverse course.” – Suzy Page, Amazon


Cover for the film, Resistance. Features a light yellow background with yellow and blue dot arranged in an "x" shape.

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